Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 5/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602121 | 0.85 | ANPEP (0.58) | ANPEPPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9590000 | 0.85 | ANPEP (0.58) | ANPEPPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6051665 | 0.81 | SLC7A5 (0.59) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL6051669 | 0.81 | SLC7A5 (0.59) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL7879302 | 0.81 | ANPEP (0.52) | ANPEPPOLBNPC1RAB9ACIT | |
| SCHEMBL29777588 | 0.80 | POLB (0.61) | ANPEPPOLBNPC1RAB9ASMN1; SMN2 | |
| Acetic Acid SCHEMBL28042956 | 0.79 | POLB (0.57) | ANPEPPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16856646 | 0.79 | PLAU (0.55) | LMNALTA4HKDM1AMAOAMAOB | |
| SCHEMBL16856328 | 0.79 | PLAU (0.55) | LMNALTA4HKDM1AMAOAMAOB | |
| SCHEMBL7873337 | 0.78 | KMT2A (0.61) | ANPEPPOLBTP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |