Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.61 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.61 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602121 | 0.89 | ANPEP (0.58) | KMT2AS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL9590000 | 0.89 | ANPEP (0.58) | KMT2AS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL7879302 | 0.88 | ANPEP (0.52) | KMT2AS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL7879201 | 0.87 | DHODH (0.49) | KMT2AS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL7873432 | 0.81 | TSHR (0.51) | S1PR1S1PR3NPC1RAB9AANPEP | |
| SCHEMBL7868057 | 0.78 | ANPEP (0.64) | NPC1RAB9AROCK2ANPEPSMN1; SMN2 | |
| SCHEMBL26741146 | 0.77 | ALDH1A1 (0.60) | S1PR1S1PR3FFAR2NPC1RAB9A | |
| SCHEMBL26741187 | 0.77 | ALDH1A1 (0.60) | S1PR1S1PR3FFAR2NPC1RAB9A | |
| SCHEMBL3988488 | 0.77 | POLB (0.43) | KMT2AS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL17664017 | 0.76 | S1PR1 (1.00) | KMT2AS1PR1S1PR3FFAR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |