Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | YARS1 | P54577 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602121 | 0.90 | ANPEP (0.58) | ANPEPSLC7A5GAACITPOLB | |
| SCHEMBL9590000 | 0.90 | ANPEP (0.58) | ANPEPSLC7A5GAACITPOLB | |
| SCHEMBL7879201 | 0.88 | DHODH (0.49) | ANPEPGAAPOLBNPC1PKM | |
| SCHEMBL7873337 | 0.88 | KMT2A (0.61) | ANPEPGAAPOLBNPC1PKM | |
| SCHEMBL7873432 | 0.82 | TSHR (0.51) | ANPEPGAACITPOLBNPC1 | |
| SCHEMBL7868057 | 0.81 | ANPEP (0.64) | ANPEPBACE1CITPOLBNPC1 | |
| SCHEMBL3988488 | 0.80 | POLB (0.43) | ANPEPSLC7A5GAAPOLBNPC1 | |
| SCHEMBL26741146 | 0.79 | ALDH1A1 (0.60) | ANPEPGAAPOLBNPC1PKM | |
| SCHEMBL16993871 | 0.79 | BACE1 (0.68) | BACE1SLC7A5GAACITLNPEP | |
| SCHEMBL26741187 | 0.79 | ALDH1A1 (0.60) | ANPEPGAAPOLBNPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |