Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403819 | 0.84 | MMP2 (0.50) | NAMPTFFAR2TSHR | |
| SCHEMBL349933 | 0.82 | NAMPT (0.80) | NAMPTHTTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29457342 | 0.82 | NAMPT (0.80) | NAMPTHTTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7501736 | 0.81 | NAMPT (0.54) | NAMPTHTTNOTUMRAB9ANPC1 | |
| SCHEMBL7501741 | 0.81 | NAMPT (0.54) | NAMPTHTTNOTUMRAB9ANPC1 | |
| SCHEMBL7501728 | 0.81 | NAMPT (0.54) | NAMPTHTTNOTUMRAB9ANPC1 | |
| SCHEMBL7494330 | 0.80 | NAMPT (0.53) | NAMPTHTTNOTUMRAB9ASMN1; SMN2 | |
| SCHEMBL7494334 | 0.80 | NAMPT (0.53) | NAMPTHTTNOTUMRAB9ASMN1; SMN2 | |
| SCHEMBL829136 | 0.79 | CTSK (0.58) | NAMPT | |
| SCHEMBL7505025 | 0.78 | HDAC4 (0.50) | NAMPTHTTNOTUMRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |