Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810817 | 0.94 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6816480 | 0.92 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6815228 | 0.86 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6814285 | 0.86 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6819726 | 0.86 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6815866 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6816335 | 0.84 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6814055 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6815797 | 0.82 | LMNA (0.57) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7571039 | 0.81 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137645-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034260-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |