Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7871688 | 0.91 | MEN1 (0.42) | MAPTLMNATDP1NPSR1MEN1 | |
| SCHEMBL7823532 | 0.88 | MAPT (0.42) | MAPTLMNATDP1KMT2ASMN1; SMN2 | |
| SCHEMBL7830193 | 0.83 | ALDH1A1 (0.35) | MAPTLMNATDP1NPSR1MEN1 | |
| SCHEMBL7815755 | 0.83 | RECQL (0.40) | MAPTLMNATDP1NPSR1MEN1 | |
| SCHEMBL7827925 | 0.83 | ALDH1A1 (0.50) | MAPTLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL8057711 | 0.82 | HTT (0.49) | MAPTLMNATDP1NPSR1MEN1 | |
| SCHEMBL7817080 | 0.81 | MAPT (0.41) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL5515200 | 0.80 | ALDH1A1 (0.47) | MAPTLMNATDP1MEN1KMT2A | |
| SCHEMBL8071450 | 0.78 | ALDH1A1 (0.47) | MAPTLMNATDP1NPSR1MEN1 | |
| SCHEMBL7827497 | 0.78 | MAPT (0.46) | MAPTLMNATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084747-C | Pyrrolobenzazepine * derivatives as neuroactive agents | ZENECA LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| CN-1224424-A | Azolobenzazepine derivs. as neurologically active agents | ZENECA LTD (GB) | 1999-07-28 | — | — | CN | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |