Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874865 | 0.77 | SMN1; SMN2 (0.39) | L3MBTL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7863144 | 0.75 | HPGD (0.48) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL7871106 | 0.75 | MAPT (0.49) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL3503761 | 0.72 | TDP1 (0.53) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL25170030 | 0.72 | TDP1 (0.53) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| Ethyl Acetate SCHEMBL27304156 | 0.72 | RAB9A (0.47) | L3MBTL1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28768690 | 0.71 | ALDH1A1 (0.47) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL1612194 | 0.71 | MAPT (0.59) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL22065260 | 0.71 | ALDH1A1 (0.51) | L3MBTL1TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL6818493 | 0.71 | RAB9A (0.42) | ALDH1A1MEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084747-C | Pyrrolobenzazepine * derivatives as neuroactive agents | ZENECA LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| CN-1224424-A | Azolobenzazepine derivs. as neurologically active agents | ZENECA LTD (GB) | 1999-07-28 | — | — | CN | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |