Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30393948 | 0.98 | TSHR (0.31) | TSHR | |
| SCHEMBL6192241 | 0.81 | TSHR (0.33) | TSHR | |
| SCHEMBL28171235 | 0.78 | ALDH1A1 (0.32) | TSHR | |
| SCHEMBL27674320 | 0.77 | — | — | |
| SCHEMBL28798967 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL28171965 | 0.76 | ALDH1A1 (0.31) | — | |
| SCHEMBL6252891 | 0.76 | ALDH1A1 (0.34) | TSHR | |
| SCHEMBL933257 | 0.75 | — | — | |
| SCHEMBL28061960 | 0.74 | — | — | |
| SCHEMBL27673745 | 0.74 | CHRM1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777142-A | Preparation method of 7-hydrogen substituted pyrazolo [1,5-a ] pyrimidine compound | 安徽中医药大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-110831600-B | Indole AHR inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| WO-2023078267-A1 | AMINO-CONTAINING MACROCYCLIC COMPOUND AS PROTEIN KINASE MODULATOR | 赛诺哈勃药业（成都）有限公司 | 2023-05-11 | — | — | WO | disclosed |
| CN-116063326-A | Amino-containing macrocyclic compounds as protein kinase modulators | 赛诺哈勃药业（成都）有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-113754682-B | Compound having macrocyclic structure and use thereof | 赛诺哈勃药业（成都）有限公司 | 2023-01-06 | — | — | CN | disclosed |
| CN-110730678-B | Pharmaceutical combination comprising an ALK inhibitor and an SHP2 inhibitor | 诺华股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110003209-B | Macrocyclic compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-113754682-A | Compounds having macrocyclic structure and uses thereof | 成都倍特药业股份有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-101362764-A | 5,7-diaminopyrazolo '4,3-d!pyrimidines with PDE-5 inhibiting activity | PFIZER (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-101362765-A | 5,7-diaminopyrazolo '4,3-d!pyrimidines with PDE-5 inhibiting activity | PFIZER (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-100439371-C | 5, 7-diaminopyrazolo [4, 3-d ] pyrimidines useful in the treatment of hypertension | PFIZER LTD (GB) | 2008-12-03 | — | — | CN | disclosed |
| CN-101175758-A | Anhydrous crystalline forms of n-[1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER (US) | 2008-05-07 | — | — | CN | disclosed |
| CN-101120000-A | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2008-02-06 | — | — | CN | disclosed |
| CN-1882591-A | 5, 7-diaminopyrazolo [4, 3-d ] pyrimidines with PDE-5 inhibiting activity | PFIZER LTD (US) | 2006-12-20 | — | — | CN | disclosed |
| CN-1802378-A | Beta-strand mimetics and methods relating thereto | CHOONGWAE PHARMA CORP (KR) | 2006-07-12 | — | — | CN | disclosed |
| CN-1780841-A | 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the traetment of hypertension | PFIZER LTD (GB) | 2006-05-31 | — | — | CN | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |
| CN-87103904-A | Weedicide | — | 1988-02-10 | — | — | CN | disclosed |