Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868957 | 0.93 | CYP3A4 (0.51) | CYP2C9CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL7874309 | 0.92 | EGFR (0.44) | CYP2C9CYP3A4LMNAMEN1MAPT | |
| SCHEMBL7875675 | 0.91 | BRD4 (0.42) | CYP2C9CYP3A4SMN1; SMN2LMNAMEN1 | |
| SCHEMBL7880231 | 0.84 | CYP3A4 (0.53) | CYP2C9CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL298104 | 0.83 | CYP2C9 (0.53) | CYP2C9CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL7869103 | 0.83 | BRAF (0.49) | CYP2C9CYP3A4CYP2C19CYP2D6CLK1 | |
| SCHEMBL7876453 | 0.83 | BTK (0.42) | PIK3CABTK | |
| SCHEMBL7880244 | 0.82 | BRAF (0.44) | CYP2C9CYP3A4CYP2C19CYP2D6CLK1 | |
| SCHEMBL7869096 | 0.82 | CYP3A4 (0.45) | CYP2C9CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL7869062 | 0.80 | CYP3A4 (0.44) | CYP2C9CYP3A4SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |