Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 19/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2099601 | 0.93 | GABRA5 (0.73) | GABRA5GABRA1 | |
| SCHEMBL2628066 | 0.93 | GABRA5 (0.73) | GABRA5GABRA1 | |
| SCHEMBL300061 | 0.93 | GABRA5 (0.73) | GABRA5GABRA1 | |
| SCHEMBL286327 | 0.85 | GABRA5 (0.71) | GABRA5GABRA1 | |
| SCHEMBL286466 | 0.84 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL286291 | 0.84 | GABRA5 (0.68) | GABRA5GABRA1 | |
| SCHEMBL286462 | 0.82 | GABRA5 (0.54) | GABRA5GABRG2GABRB3GABRA1 | |
| SCHEMBL286356 | 0.82 | GABRA5 (0.54) | GABRA5GABRG2GABRB3GABRA1 | |
| SCHEMBL286126 | 0.82 | GABRA5 (0.54) | GABRA5GABRG2GABRB3GABRA1 | |
| SCHEMBL286344 | 0.82 | GABRA5 (0.67) | GABRA5GABRG2GABRB3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127975-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |