Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869457 | 0.90 | P4HTM (0.47) | P4HTMSMN1; SMN2 | |
| SCHEMBL7871640 | 0.90 | RAB9A (0.52) | P4HTMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7867790 | 0.89 | MEN1 (0.48) | P4HTMBCL2L1MCL1NPC1RAB9A | |
| SCHEMBL7871609 | 0.89 | P4HTM (0.55) | P4HTMPTGS2PTGS1EGFRGABRA5 | |
| SCHEMBL7870451 | 0.88 | NPC1 (0.46) | P4HTMEGFRGABRA5BCL2L1MCL1 | |
| SCHEMBL7867895 | 0.88 | NPC1 (0.51) | P4HTMEGFRGABRA5BCL2L1MCL1 | |
| SCHEMBL9574778 | 0.88 | P4HTM (0.43) | P4HTMEGFRBCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL7862856 | 0.88 | HSP90AA1 (0.46) | P4HTMEGFRGABRA5BCL2L1MCL1 | |
| SCHEMBL7871681 | 0.87 | EGFR (0.46) | P4HTMPTGS2EGFRGABRA5 | |
| SCHEMBL7874499 | 0.87 | P4HTM (0.58) | P4HTMEGFRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |