Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870344 | 0.94 | EPHX2 (0.43) | EPHX2EGFRP4HTMCYP2C9CYP2C19 | |
| SCHEMBL7870559 | 0.93 | EGFR (0.41) | EPHX2EGFRP4HTMCYP2C9CYP2C19 | |
| SCHEMBL7870444 | 0.91 | P4HTM (0.46) | EPHX2EGFRP4HTMCYP2C9CYP2C19 | |
| SCHEMBL7874560 | 0.90 | SCN3A (0.44) | EPHX2EGFRP4HTML3MBTL1 | |
| SCHEMBL7874499 | 0.86 | P4HTM (0.58) | EGFRP4HTMCYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8869196 | 0.86 | P4HTM (0.53) | EPHX2EGFRP4HTMCYP2C9CYP2C19 | |
| SCHEMBL7867676 | 0.86 | EPHX2 (0.42) | EPHX2CYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7871651 | 0.86 | BCL2L1 (0.46) | EGFRP4HTMMEN1KMT2ANPC1 | |
| SCHEMBL7870555 | 0.85 | EGFR (0.43) | EPHX2EGFRP4HTMCYP2C9CYP2C19 | |
| SCHEMBL7870464 | 0.84 | BCL2L1 (0.45) | L3MBTL1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |