SCHEMBL7869656

SCHEMBL7869656

CCCCOC/C(=C\C(Cl)(Cl)Cl)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.41
EPHX2 P34913 1/20 0.35
ATM Q13315 1/20 0.35
HCAR2 Q8TDS4 2/20 0.35
TSHR P16473 3/20 0.34
PLA2G4B P0C869 3/20 0.34
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
RECQL P46063 1/20 0.32
PTGES O14684 2/20 0.32
ALOX5 P09917 2/20 0.32
PPARG P37231 1/20 0.32
RARB P10826 1/20 0.31
GRIK1 P39086 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7869661 1.00 CES2 (0.41) CES2EPHX2ATMHCAR2TSHR
SCHEMBL7868955 0.82 KDM4E (0.32) ALDH1A1GRIK1
SCHEMBL2416653 0.77 ALDH1A1 (0.41) CES2TSHRALDH1A1PPARG
SCHEMBL2416656 0.77 ALDH1A1 (0.41) CES2TSHRALDH1A1PPARG
SCHEMBL8682392 0.75 AKR1B1 (0.45) CES2TSHRALDH1A1RECQLPPARG
SCHEMBL1274486 0.73 CES2 (0.41) CES2EPHX2ATMHCAR2TSHR
SCHEMBL2418563 0.72 FFAR3 (0.35) TSHRGRIK1
SCHEMBL7866317 0.70 GRIK1 (0.33) GRIK1
SCHEMBL7869599 0.70 ATM (0.43) ATMHCAR2TSHRALDH1A1HPGD
SCHEMBL7869596 0.70 ATM (0.43) ATMHCAR2TSHRALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124786-A1 PROCESS FOR THE PREPARATION AND USES OF DERIVATIVES OF ESTERS OF ALPHA-METHYLENE- BETA-HYDROXY ACIDS Uniroyal Chemical Company, Inc. (US) 2001-08-22 EP claimed
WO-2000027793-A1 PROCESS FOR THE PREPARATION AND USES OF DERIVATIVES OF ESTERS OF ALPHA- METHYLENE- BETA- HYDROXY ACIDS UNIROYAL CHEMICAL COMPANY, INC. (US) 2000-05-18 WO claimed
US-6310237-B1 REACTIONS OF ALPHA-UNSATURATED CARBOXY ACIDS, ESTERS, AMIDES OR THIOESTERS WITH OF 1.) A LEWIS ACID OR BASE OR 2.) HYDROGEN AND TRANSITION METALS OR THEIR OXIDES, OR 3.) ALKYL ALUMINUMS, ALKYL HYDRIDES, SOLUBLE NICKEL OR PALLADIUM SALTS UNIROYAL CHEMICAL COMPANY, INC. 2001-10-30 US disclosed
US-6147251-A PREPARATION OF DERIVATIVES OF HALO-BUT-2-ENOIC ACIDS AND ESTERS HIGH IN 2-ENE CONTENT; CATALYST PROMOTERS IN ETHYLENE POLYMERIZATION AND COPOLYMERIZATION UNIROYAL CHEMICAL COMPANY, INC. (US) 2000-11-14 US disclosed