Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629576 | 0.86 | MAPT (0.48) | MEN1KMT2AABCG2ABCC1ABCB1 | |
| SCHEMBL629558 | 0.82 | KMT2A (0.48) | MEN1KMT2AABCG2ABCC1ABCB1 | |
| SCHEMBL10559120 | 0.75 | MEN1 (0.62) | MEN1KMT2AABCG2ABCC1ABCB1 | |
| SCHEMBL21848229 | 0.71 | GAA (0.51) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL25230316 | 0.70 | TXNRD1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL386231 | 0.70 | LMNA (0.61) | MEN1KMT2AABCG2ABCC1ABCB1 | |
| SCHEMBL13838818 | 0.70 | LMNA (0.57) | MEN1KMT2AABCG2PTGS2ALDH1A1 | |
| SCHEMBL12574434 | 0.69 | MAPK1 (0.47) | MEN1KMT2AALDH1A1LMNATDP1 | |
| SCHEMBL7878184 | 0.69 | MEN1 (0.55) | MEN1KMT2AABCG2ABCC1ABCB1 | |
| SCHEMBL1053271 | 0.68 | FYN (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120998-A1 | PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |