SCHEMBL7869868

SCHEMBL7869868

C=Cc1c(C(=O)O)ccc(C)c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A6 Q4U2R8 2/20 0.51
SLC22A8 Q8TCC7 2/20 0.51
HAAO P46952 1/20 0.39
CYP1A2 P05177 3/20 0.38
MEN1 O00255 1/20 0.38
AKR1B10 O60218 1/20 0.38
TRPA1 O75762 1/20 0.38
ABCB11 O95342 1/20 0.38
DHFR P00374 1/20 0.38
LMNA P02545 1/20 0.38
MPO P05164 1/20 0.38
CYP3A4 P08684 1/20 0.38
CHRM1 P11229 1/20 0.38
CYP2C9 P11712 1/20 0.38
AKR1B1 P15121 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27479146 0.83 SLC22A6 (0.47) SLC22A6SLC22A8HAAOCYP1A2CYP3A4
SCHEMBL31084599 0.83 SLC22A8 (0.66) SLC22A6SLC22A8CYP1A2PTGS2ALDH1A1
SCHEMBL12760673 0.82 CYP3A4 (0.41) SLC22A6SLC22A8HAAOCYP1A2MEN1
SCHEMBL28841150 0.81 SLC22A6 (0.46) SLC22A6SLC22A8HAAOCYP1A2ALDH1A1
SCHEMBL332990 0.81 CYP1A2 (0.50) SLC22A6SLC22A8CYP1A2CYP3A4PTGS2
Propene SCHEMBL28186167 0.79 SLC22A6 (0.49) SLC22A6SLC22A8HAAOCYP1A2CYP3A4
SCHEMBL31338864 0.77 ALDH1A1 (0.55) SLC22A6SLC22A8CYP1A2MEN1AKR1B10
SCHEMBL357340 0.77 ALDH1A1 (0.55) SLC22A6SLC22A8CYP1A2MEN1AKR1B10
SCHEMBL12495244 0.76 TSHR (0.55) SLC22A6SLC22A8MEN1LMNACYP3A4
SCHEMBL29370019 0.74 CYP1A2 (0.48) HAAOCYP1A2MEN1AKR1B10TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106536508-A ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE 武田药品工业株式会社 2017-03-22 CN disclosed
EP-3134386-A1 ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE Takeda Pharmaceutical Company Limited (JP) 2017-03-01 EP disclosed
WO-2015163485-A1 ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-29 WO disclosed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed