SCHEMBL7869893

SCHEMBL7869893

COc1ccc([SiH2]c2ccc(OC)c3c2Cc2ccccc2-3)c2c1-c1ccccc1C2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.47
ALDH1A1 P00352 5/20 0.47
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
KDM4E B2RXH2 4/20 0.47
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
USP2 O75604 1/20 0.42
DUSP3 P51452 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
HTR2C P28335 1/20 0.40
HIF1A Q16665 1/20 0.39
PTGS2 P35354 2/20 0.39
GAA P10253 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CASP3 P42574 1/20 0.38
CASP6 P55212 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7873606 0.93 MAPT (0.42) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL11422117 0.79 ALDH1A1 (0.51) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL7873112 0.79 MAPT (0.48) MAPTALDH1A1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL7196660 0.78 MAPT (0.47) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL7945496 0.77 MAPT (0.46) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL7196670 0.76 MAPT (0.45) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL3286498 0.73 PTGS2 (0.49) MAPTALDH1A1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL7876357 0.73 MAPT (0.42) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL28290229 0.71 MAPT (0.46) MAPTALDH1A1MEN1KMT2AKDM4E
Ethylene SCHEMBL7873619 0.70 PTGS2 (0.46) MAPTALDH1A1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313242-B1 PROVIDING A METALLOCENE CATALYST AND CONTACTING WITH AN ETHYLENICALLY UNSATURATED MONOMER WHICH CONTAINS THREE OR MORE CARBON ATOMS OR IS A SUBSTITUTED VINYL COMPOUND IN PRESENCE OF ORGANOALUMINUM COCATALYST TO PRODUCE ISOSPECIFIC POLYMER FINA TECHNOLOGY, INC. 2001-11-06 US disclosed
US-5945365-A Stereorigid bis-fluorenyl metallocenes FINA TECHNOLOGY, INC. (US) 1999-08-31 US disclosed