SCHEMBL7870000

SCHEMBL7870000

CNC(Cc1ccccc1)OC

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 7/20 0.55
TAAR1 Q96RJ0 5/20 0.55
SLC18A2 Q05940 1/20 0.55
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 1/20 0.44
SLC6A2 P23975 2/20 0.43
MAOA P21397 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
CYP2A6 P11509 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
EPHX1 P07099 1/20 0.41
LTA4H P09960 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21243266 0.85 SIGMAR1 (0.47) SIGMAR1TAAR1SLC18A2CYP2D6SLC6A2
SCHEMBL3009950 0.82 SIGMAR1 (0.53) SIGMAR1TAAR1SLC18A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL11525467 0.80 TAAR1 (0.45) SIGMAR1TAAR1SLC18A2CYP2D6SLC6A2
SCHEMBL5544627 0.79 NPC1 (0.53) TAAR1CYP2C19
SCHEMBL8504186 0.78 TAAR1 (0.60) SIGMAR1TAAR1
SCHEMBL7440650 0.77 TAAR1 (0.61) SIGMAR1TAAR1SLC18A2SLC6A2MAOA
SCHEMBL794607 0.76 SIGMAR1 (0.41) SIGMAR1TAAR1SLC18A2CYP2D6SLC6A2
SCHEMBL20357548 0.76 SIGMAR1 (0.42) SIGMAR1TAAR1SLC6A2MAOASLC6A4
SCHEMBL18995752 0.76 TAAR1 (0.47) SIGMAR1TAAR1SLC18A2SLC6A2MAOA
SCHEMBL14764261 0.75 TAAR1 (0.52) SIGMAR1TAAR1SLC18A2CYP2D6SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308456-B1 COMPOSITON FOR THE TREATMENT OF THE EPIDERM SCHOEFF, Nadine (FR) 1991-12-04 EP claimed
EP-0808303-B1 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST ASTRAZENECA AB (SE) 2001-06-20 EP disclosed
EP-0808303-A1 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST ZENECA LIMITED (GB) 1997-11-26 EP disclosed
WO-1996024582-A1 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST ZENECA LIMITED (GB) 1996-08-15 WO disclosed