Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076699 | 0.84 | NPC1 (0.49) | NPC1RAB9ACTRB1ALDH1A1MMP8 | |
| SCHEMBL14927646 | 0.84 | CTRB1 (0.61) | NPC1RAB9AATMCTRB1ALDH1A1 | |
| SCHEMBL3400152 | 0.82 | CTRB1 (0.48) | NPC1RAB9ACTRB1ALDH1A1CYP2C9 | |
| SCHEMBL17747125 | 0.82 | TACR1 (0.47) | NPC1 | |
| SCHEMBL21243266 | 0.80 | SIGMAR1 (0.47) | NPC1RAB9ATAAR1 | |
| SCHEMBL9545301 | 0.80 | NPC1 (0.44) | NPC1RAB9AATMCTRB1ALDH1A1 | |
| SCHEMBL7870000 | 0.79 | SIGMAR1 (0.55) | CYP2C19TAAR1 | |
| SCHEMBL9782008 | 0.78 | TSHR (0.48) | NPC1RAB9ACTRB1MMP8POLB | |
| SCHEMBL3062497 | 0.78 | NOS3 (0.51) | NPC1RAB9ACTRB1CYP2C9CYP2C19 | |
| SCHEMBL22321660 | 0.77 | PIN1 (0.51) | NPC1RAB9ACTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |