Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24843632 | 0.79 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL612377 | 0.76 | GRM5 (0.49) | PIK3C3AOC3LMNAALDH1A1KDM4E | |
| SCHEMBL19491511 | 0.76 | PIK3C3 (0.40) | PIK3C3AOC3LMNAALDH1A1MAPK1 | |
| SCHEMBL7880330 | 0.76 | DPP4 (0.36) | AOC3LMNAALDH1A1KDM4EMAPK1 | |
| SCHEMBL7870251 | 0.74 | PIK3C3 (0.41) | PIK3C3TLR8 | |
| SCHEMBL7869375 | 0.74 | MAPK1 (0.34) | AOC3LMNAALDH1A1KDM4EMAPK1 | |
| SCHEMBL18266150 | 0.73 | AOC3 (0.47) | PIK3C3AOC3LMNAALDH1A1KDM4E | |
| SCHEMBL17177772 | 0.71 | ALDH1A1 (0.38) | PIK3C3LMNAALDH1A1MEN1MAPT | |
| SCHEMBL20780788 | 0.69 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL19936158 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139747-A1 | 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2010-12-09 | — | — | WO | disclosed |