Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869947 | 0.82 | ALDH1A1 (0.49) | SMN1; SMN2MAPTALDH1A1LMNATP53 | |
| SCHEMBL29318964 | 0.77 | ALDH1A1 (0.50) | MAPTALDH1A1LMNATDP1POLB | |
| SCHEMBL5510643 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2MAPTALDH1A1LMNATP53 | |
| SCHEMBL25336401 | 0.73 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNATP53POLB | |
| SCHEMBL5512049 | 0.73 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNATP53POLB | |
| SCHEMBL29117071 | 0.73 | SMN1; SMN2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4SMN1; SMN2 | |
| SCHEMBL5932403 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2MAPTALDH1A1LMNATP53 | |
| SCHEMBL13603966 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1LMNATP53POLB | |
| SCHEMBL29024419 | 0.72 | TP53 (0.42) | SMN1; SMN2MAPTALDH1A1TP53HSD17B10 | |
| SCHEMBL30796294 | 0.72 | SMN1; SMN2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |