Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881266 | 0.87 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1065677 | 0.87 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL899628 | 0.82 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6644159 | 0.79 | LMNA (0.56) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7184918 | 0.78 | TSHR (0.82) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3451560 | 0.78 | TSHR (0.75) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10520781 | 0.77 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10332625 | 0.76 | LMNA (0.67) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5774615 | 0.76 | LMNA (0.59) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6642289 | 0.75 | KDM4E (0.54) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |