Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862781 | 0.95 | POLB (0.43) | POLBMAPTTDP1EGFREPHX2 | |
| SCHEMBL7867840 | 0.94 | POLB (0.42) | POLBMAPTTDP1EGFREPHX2 | |
| SCHEMBL8868884 | 0.90 | CYP3A4 (0.42) | POLBMAPTTDP1CYP3A4CYP2C9 | |
| SCHEMBL9018277 | 0.90 | POLB (0.42) | POLBMAPTTDP1EGFREPHX2 | |
| SCHEMBL7870463 | 0.89 | KMT2A (0.46) | MAPTEGFRHPGDNPC1HTT | |
| SCHEMBL7874495 | 0.88 | ALDH1A1 (0.46) | POLBMAPTTDP1CYP3A4CYP2C9 | |
| SCHEMBL9018491 | 0.87 | MAPT (0.40) | POLBMAPTTDP1EGFREPHX2 | |
| SCHEMBL7862784 | 0.87 | HPGD (0.46) | CYP3A4CYP2C9CYP2C19CCR2CCR4 | |
| SCHEMBL8869340 | 0.86 | POLB (0.44) | POLBMAPTTDP1CYP3A4CYP2C9 | |
| SCHEMBL7874624 | 0.86 | PTGDR (0.42) | POLBMAPTEPHX2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |