Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867706 | 0.94 | HPGD (0.48) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7874495 | 0.92 | ALDH1A1 (0.46) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8869753 | 0.90 | NPC1 (0.50) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9018349 | 0.89 | ALDH1A1 (0.49) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7867895 | 0.88 | NPC1 (0.51) | HPGDNPC1RAB9ASMN1; SMN2BCL2L1 | |
| SCHEMBL7870551 | 0.87 | RAB9A (0.49) | HPGDNPC1RAB9ASMN1; SMN2BCL2L1 | |
| SCHEMBL7870537 | 0.87 | POLB (0.41) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9018281 | 0.86 | ALDH1A1 (0.47) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7867692 | 0.85 | SMN1; SMN2 (0.44) | HPGDNPC1RAB9ASMN1; SMN2CA1 | |
| SCHEMBL8869616 | 0.84 | HPGD (0.52) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |