SCHEMBL7871534

SCHEMBL7871534

CCOC(=O)C1=C(c2cccc(-c3ccsc3)c2)NC(C)=C(C(=O)OCC#Cc2cccnc2)C1CCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 10/20 0.42
TRPV1 Q8NER1 2/20 0.39
CACNA1C Q13936 1/20 0.38
TMIGD3 P0DMS9 2/20 0.38
GAA P10253 1/20 0.37
MAPK1 P28482 2/20 0.37
MAPT P10636 1/20 0.37
CYP3A4 P08684 1/20 0.37
ALDH1A1 P00352 3/20 0.36
LMNA P02545 1/20 0.36
ALOX12 P18054 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7872523 0.94 ADORA3 (0.43) ADORA3TRPV1TMIGD3GAAMAPK1
SCHEMBL7869546 0.84 ADORA3 (0.41) ADORA3TRPV1CACNA1CTMIGD3GAA
SCHEMBL7873220 0.83 ADORA3 (0.45) ADORA3TRPV1TMIGD3GAAMAPK1
SCHEMBL7873224 0.82 ADORA3 (0.40) ADORA3TRPV1CACNA1CTMIGD3GAA
SCHEMBL8144758 0.81 ADORA3 (0.39) ADORA3TRPV1CACNA1CTMIGD3GAA
SCHEMBL7876057 0.81 ADORA3 (0.42) ADORA3TRPV1CACNA1CTMIGD3GAA
SCHEMBL7871558 0.80 ADORA3 (0.43) ADORA3TRPV1CACNA1CTMIGD3GAA
SCHEMBL7872517 0.80 ADORA3 (0.38) ADORA3TRPV1CACNA1CTMIGD3MAPK1
SCHEMBL7876025 0.80 ALDH1A1 (0.42) ADORA3TRPV1TMIGD3GAAMAPK1
SCHEMBL7871453 0.78 ADORA3 (0.41) ADORA3TRPV1CACNA1CTMIGD3GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306853-B1 DICARBOXYLIC ESTER DERIVATIVES OF DIHYDROPYRIDINE COMPOUNDS NIKKEN CHEMICALS CO., LTD. (JP) 2001-10-23 US disclosed
EP-1055672-A1 1,4-DIHYDROPYRIDINE DERIVATIVES Nikken Chemicals Company, Limited (JP) 2000-11-29 EP disclosed