Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA7 | P43166 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870522 | 0.93 | NPC1 (0.44) | NPC1RAB9AMAPTGABRA5SMN1; SMN2 | |
| SCHEMBL7869411 | 0.93 | RAB9A (0.48) | NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7874604 | 0.92 | RAB9A (0.44) | NPC1RAB9AMAPTGABRA5SMN1; SMN2 | |
| SCHEMBL7867914 | 0.92 | SMN1; SMN2 (0.46) | NPC1RAB9AMAPTGABRA5SMN1; SMN2 | |
| SCHEMBL7869433 | 0.91 | MAPT (0.50) | NPC1RAB9AMAPTGABRA5SMN1; SMN2 | |
| SCHEMBL7870592 | 0.91 | MAPT (0.50) | NPC1RAB9AMAPTGABRA5SMN1; SMN2 | |
| SCHEMBL7874593 | 0.90 | MAPT (0.51) | NPC1RAB9AMAPTSMN1; SMN2CA1 | |
| SCHEMBL7870462 | 0.89 | NPC1 (0.39) | NPC1RAB9AMAPTSMN1; SMN2CA1 | |
| SCHEMBL7862782 | 0.89 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL9018287 | 0.88 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |