Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7871573 | 0.93 | NPC1 (0.45) | NPC1RAB9AGABRA5SMN1; SMN2MAPT | |
| SCHEMBL7862782 | 0.92 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7871592 | 0.92 | AKR1C3 (0.46) | NPC1RAB9AGABRA5SMN1; SMN2ALDH1A1 | |
| SCHEMBL7870592 | 0.91 | MAPT (0.50) | NPC1RAB9AGABRA5SMN1; SMN2MAPT | |
| SCHEMBL7869433 | 0.91 | MAPT (0.50) | NPC1RAB9AGABRA5SMN1; SMN2MAPT | |
| SCHEMBL7870457 | 0.90 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8869497 | 0.89 | NPC1 (0.48) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7869411 | 0.88 | RAB9A (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9018255 | 0.88 | ALDH1A1 (0.46) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7870454 | 0.88 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |