Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666850 | 0.83 | ALDH1A1 (0.48) | ALDH1A1ESR1HIF1AKMT2ALMNA | |
| Ammonia Solution, Strong SCHEMBL28310523 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ESR1HIF1AKMT2ALMNA | |
| SCHEMBL9724792 | 0.81 | MAPT (0.51) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL27484392 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL11815316 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL2987920 | 0.77 | PRSS1 (0.51) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL7260994 | 0.77 | PARP10 (0.46) | ALDH1A1KMT2AMAPTSMN1; SMN2ELANE | |
| SCHEMBL2636796 | 0.77 | ALDH1A1 (0.43) | ALDH1A1ESR1HIF1AKMT2ALMNA | |
| SCHEMBL2170541 | 0.74 | PRSS1 (0.51) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL27733707 | 0.74 | TDP1 (0.51) | ALDH1A1ESR1HIF1AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |