SCHEMBL7871901

SCHEMBL7871901

Cc1ccc(COCC2CCN(CC3CN(Cc4ccc(Cl)cc4Cl)CC3c3ccsc3)CC2)cc1

nearest known ligand 0.40

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 5/20 0.40
KDM4E B2RXH2 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MCHR1 Q99705 1/20 0.34
CXCR4 P61073 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7871904 1.00 CCR5 (0.40) CCR5KDM4ETDP1MCHR1CXCR4
SCHEMBL7863308 0.95 CCR5 (0.42) CCR5KDM4ETDP1
SCHEMBL7863310 0.95 CCR5 (0.42) CCR5KDM4ETDP1
SCHEMBL7868366 0.92 CCR5 (0.40) CCR5
SCHEMBL7868364 0.92 CCR5 (0.40) CCR5
SCHEMBL7863096 0.92 CCR5 (0.48) CCR5
SCHEMBL7863247 0.91 CCR5 (0.40) CCR5KDM4ETDP1MCHR1
SCHEMBL7863248 0.91 CCR5 (0.40) CCR5KDM4ETDP1MCHR1
SCHEMBL7868450 0.91 CCR5 (0.42) CCR5KDM4ETDP1
SCHEMBL7868448 0.91 CCR5 (0.42) CCR5KDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US claimed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed