Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883169 | 0.84 | KAT2B (0.51) | MEN1KMT2AMAPTFBP1TDP1 | |
| SCHEMBL2331032 | 0.83 | AKR1C3 (0.60) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2212705 | 0.82 | AKR1C3 (0.68) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2324743 | 0.81 | AKR1C3 (0.60) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL28853179 | 0.81 | TDP1 (0.62) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL4930929 | 0.79 | MAPT (0.68) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2327235 | 0.79 | AKR1C3 (0.53) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2328747 | 0.79 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL11901725 | 0.78 | MEN1 (0.62) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL7872403 | 0.77 | TXNRD1 (0.48) | MEN1KMT2AMAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | claimed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | claimed |
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |