Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.64 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557655 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL6867419 | 0.76 | REN (0.71) | RENKCNH2CYP3A4 | |
| SCHEMBL11898945 | 0.76 | REN (0.71) | RENKCNH2CYP3A4 | |
| SCHEMBL10202609 | 0.76 | REN (0.85) | RENKCNH2CYP3A4 | |
| SCHEMBL7871795 | 0.76 | REN (0.59) | RENKCNH2CYP3A4 | |
| SCHEMBL557022 | 0.75 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL10202685 | 0.74 | REN (0.89) | RENKCNH2CYP3A4 | |
| SCHEMBL557139 | 0.74 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL7863764 | 0.74 | REN (0.58) | RENKCNH2CYP3A4IKBKB | |
| Hydrochloric Acid SCHEMBL557358 | 0.74 | REN (0.88) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |