Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | BCL2 | P10415 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645116 | 0.86 | MALT1 (0.50) | PTGS2PTGS1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9202494 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7867785 | 0.82 | PTGS2 (0.47) | PTGS2PTGS1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7465856 | 0.82 | PTGS2 (0.54) | PTGS2PTGS1LMNAMALT1ALOX5 | |
| SCHEMBL7874456 | 0.80 | PTGS2 (0.46) | PTGS2PTGS1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7878950 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1SMN1; SMN2POLBMALT1 | |
| SCHEMBL7876568 | 0.80 | POLB (0.46) | PTGS2PTGS1LMNASMN1; SMN2MEN1 | |
| SCHEMBL8640795 | 0.80 | KDM4C (0.50) | PTGS2PTGS1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8639378 | 0.79 | PTGS2 (0.53) | PTGS2PTGS1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7872834 | 0.77 | PTGS2 (0.46) | PTGS2PTGS1KCNH2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |