Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | RPA1 | P27694 | 4/20 | 0.47 |
| ▸ | RARG | P13631 | 4/20 | 0.47 |
| ▸ | RXRA | P19793 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641532 | 0.82 | PTGS2 (0.69) | PTGS2PTGS1MAPTCYP2C9 | |
| SCHEMBL7456119 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1RPA1RARGRXRA | |
| SCHEMBL8645116 | 0.82 | MALT1 (0.50) | PTGS2PTGS1RPA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9202494 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7465856 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1RPA1CYP1A2CYP2C9 | |
| SCHEMBL7872838 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1RPA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7867785 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8639378 | 0.79 | PTGS2 (0.53) | PTGS2PTGS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8923289 | 0.78 | CA9 (0.58) | RPA1ALDH1A1HPGDSMN1; SMN2TP53 | |
| SCHEMBL7874456 | 0.78 | PTGS2 (0.46) | PTGS2PTGS1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |