Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.64 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.64 |
| ▸ | BCL2 | P10415 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398834 | 1.00 | CYP4F2 (0.64) | CYP4F2CYP4A11BCL2EGFRDHFR | |
| SCHEMBL17164349 | 0.89 | CYP4F2 (0.66) | CYP4F2CYP4A11DHFRLOXL2CA1 | |
| SCHEMBL30506526 | 0.89 | CYP4F2 (0.66) | CYP4F2CYP4A11DHFRLOXL2CA1 | |
| SCHEMBL17740358 | 0.88 | BCL2 (0.71) | CYP4F2CYP4A11BCL2EGFRDHFR | |
| SCHEMBL6714949 | 0.86 | EGFR (0.60) | CYP4F2CYP4A11BCL2EGFRDHFR | |
| SCHEMBL1318407 | 0.85 | HSD17B2 (0.54) | CYP4F2CYP4A11BCL2EGFRDHFR | |
| SCHEMBL4726691 | 0.85 | BCL2 (0.56) | CYP4F2CYP4A11BCL2CA1CA2 | |
| SCHEMBL259 | 0.85 | CA12 (0.59) | CYP4F2CYP4A11DHFRLOXL2CA1 | |
| SCHEMBL7021444 | 0.84 | LOXL2 (0.59) | CYP4F2CYP4A11LOXL2CA1CA2 | |
| SCHEMBL28189889 | 0.84 | EGFR (0.68) | EGFRLOXL2CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024260023-A1 | CYCLIC Α-HYDROXYIMIDE COMPOUND AND USE THEREOF | 北京英飞智药科技有限公司 | 2024-12-26 | — | — | WO | disclosed |
| US-8748632-B2 | Positive allosteric modulators of group II mGluRs | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-03-22 | — | — | US | disclosed |
| WO-2011116356-A2 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | GRM2, GRM1, GRIN2C | CYP4F2 3587/4885CYP4A11 4166/4885BCL2 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.