Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17740358 | 0.89 | BCL2 (0.71) | EGFRBCL2DHFRCYP4A11CYP4F2 | |
| SCHEMBL31398834 | 0.86 | CYP4F2 (0.64) | EGFRBCL2DHFRCYP4A11CYP4F2 | |
| SCHEMBL787303 | 0.86 | CYP4F2 (0.64) | EGFRBCL2DHFRCYP4A11CYP4F2 | |
| SCHEMBL4729076 | 0.85 | BCL2 (0.57) | BCL2CYP4A11CYP4F2CA1CA2 | |
| SCHEMBL28189889 | 0.85 | EGFR (0.68) | EGFRLOXL2CA1CA2CA12 | |
| SCHEMBL6481471 | 0.84 | CA12 (0.61) | EGFRDHFRCYP4A11CYP4F2LOXL2 | |
| SCHEMBL14548348 | 0.84 | BCL2 (0.53) | EGFRBCL2DHFRACMSDPRKCI | |
| SCHEMBL1318407 | 0.84 | HSD17B2 (0.54) | EGFRBCL2DHFRCYP4A11CYP4F2 | |
| SCHEMBL5893077 | 0.83 | LOXL2 (0.61) | EGFRCYP4A11CYP4F2LOXL2CA1 | |
| SCHEMBL9939192 | 0.83 | EGFR (0.51) | EGFRCYP4A11CYP4F2LOXL2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | disclosed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | disclosed |
| US-20040006141-A1 | Amidocarboxylic acid compounds | SANKYO COMPANY, LTD (JP) | 2004-01-08 | — | — | US | disclosed |
| US-6528525-B1 | Amidocarboxylic acid derivatives | SANKYO COMPANY, LIMITED (JP) | 2003-03-04 | — | — | US | disclosed |
| EP-1026149-A1 | AMIDOCARBOXYLIC ACID DERIVATIVES | Sankyo Company Limited (JP) | 2000-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006141-A1 | Amidocarboxylic acid compounds | NR1H2, AGK, APOL1 | EGFR 629/4885BCL2 1359/4885DHFR 2034/4885 |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | MICA, VIP, NPEPPS | EGFR 2919/4885BCL2 3764/4885DHFR 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.