Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865767 | 0.85 | POLB (0.47) | MEN1KMT2ARAB9AALDH1A1POLB | |
| SCHEMBL173527 | 0.83 | MEN1 (0.60) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL30753398 | 0.83 | MEN1 (0.60) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL19568219 | 0.81 | GAA (0.50) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL13246382 | 0.80 | GAA (0.63) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL687148 | 0.80 | GAA (0.68) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL3443268 | 0.80 | IDO1 (0.58) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL29493316 | 0.80 | GAA (0.68) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL25649096 | 0.79 | RAB9A (0.47) | MEN1KMT2AGAAIDO1RAB9A | |
| SCHEMBL28014773 | 0.78 | MEN1 (0.55) | MEN1KMT2AGAAIDO1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |