Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 6/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865716 | 0.86 | GLS (0.49) | GLSBRD4CREBBPNAMPTKDM4A | |
| SCHEMBL23413688 | 0.84 | GLS (0.46) | GLSBRD4CREBBPKDM4AHDAC1 | |
| SCHEMBL13715120 | 0.79 | GLS (0.46) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL12318659 | 0.79 | GLS (0.49) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL21089822 | 0.78 | GLS (0.48) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL28637112 | 0.78 | GLS (0.48) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL27779357 | 0.77 | GLS (0.47) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL14898071 | 0.77 | GLS (0.48) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL10208317 | 0.76 | GLS (0.57) | GLSL3MBTL1BRD4CREBBPNAMPT | |
| SCHEMBL5264017 | 0.75 | GLS (0.51) | GLSBRD4CREBBPNAMPTKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |