SCHEMBL7873283

SCHEMBL7873283

CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)OCC#Cc2cccnc2)C1CCc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 8/20 0.40
TMIGD3 P0DMS9 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPK1 P28482 1/20 0.37
TSHR P16473 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8143535 0.96 ADORA3 (0.40) ADORA3TMIGD3TRPV1CYP3A4MAPK1
SCHEMBL7869551 0.95 ADORA3 (0.39) ADORA3TMIGD3TRPV1CYP3A4MAPK1
SCHEMBL7864221 0.94 ADORA3 (0.40) ADORA3TMIGD3TRPV1CYP3A4MAPK1
SCHEMBL7864225 0.93 ADORA3 (0.41) ADORA3TMIGD3CYP3A4MAPK1TSHR
SCHEMBL8135837 0.93 ADORA3 (0.34) ADORA3CYP3A4MAPK1TSHR
SCHEMBL8142233 0.93 CACNA1C (0.39) ADORA3TMIGD3CYP3A4MAPK1TSHR
SCHEMBL8144758 0.93 ADORA3 (0.39) ADORA3TMIGD3TRPV1CYP3A4MAPK1
SCHEMBL7876072 0.93 ADORA3 (0.39) ADORA3TMIGD3TRPV1CYP3A4MAPK1
SCHEMBL7873275 0.92 ADORA3 (0.34) ADORA3TMIGD3CYP3A4MAPK1TSHR
SCHEMBL7869561 0.92 ADORA3 (0.36) ADORA3TMIGD3TRPV1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306853-B1 DICARBOXYLIC ESTER DERIVATIVES OF DIHYDROPYRIDINE COMPOUNDS NIKKEN CHEMICALS CO., LTD. (JP) 2001-10-23 US disclosed
EP-1055672-A1 1,4-DIHYDROPYRIDINE DERIVATIVES Nikken Chemicals Company, Limited (JP) 2000-11-29 EP disclosed