Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584650 | 0.85 | KMT2A (0.37) | MCL1BCL2L1KDM4ERORCALDH1A1 | |
| SCHEMBL7584634 | 0.80 | NPC1 (0.39) | MCL1BCL2L1KDM4ERORCALDH1A1 | |
| SCHEMBL6392313 | 0.79 | KEAP1 (0.37) | MAPTRORCALDH1A1MEN1KMT2A | |
| SCHEMBL6387295 | 0.75 | RORC (0.33) | MCL1BCL2L1RORCALDH1A1 | |
| SCHEMBL7584054 | 0.75 | KMT2A (0.39) | MCL1BCL2L1KDM4ERORCALDH1A1 | |
| SCHEMBL7876543 | 0.74 | KEAP1 (0.39) | MAPTRORCALDH1A1MEN1KMT2A | |
| SCHEMBL6395395 | 0.74 | KEAP1 (0.36) | MCL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7450756 | 0.73 | CYP2C8 (0.33) | MCL1BCL2L1MAPT | |
| SCHEMBL7587276 | 0.73 | KMT2A (0.37) | MCL1BCL2L1KDM4ERORCALDH1A1 | |
| SCHEMBL7458622 | 0.72 | RORC (0.45) | MCL1BCL2L1RORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316496-B1 | FOR THERAPY OF RETROVIRAL INFECTION; PROPHYLAXIS OF REPLICATION OF RETROVIRUS, THERAPY OF AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) | G. D. SEARLE & CO. | 2001-11-13 | — | — | US | disclosed |