Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873377 | 0.77 | EPHX2 (0.48) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 | |
| SCHEMBL1515626 | 0.76 | NPC1 (0.53) | KMT2ASMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL7472155 | 0.75 | KMT2A (0.63) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 | |
| SCHEMBL28287261 | 0.75 | KMT2A (0.63) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 | |
| SCHEMBL1515392 | 0.72 | NPC1 (0.58) | KMT2ASMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL8889652 | 0.71 | NPC1 (0.46) | KMT2ASMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL19169564 | 0.70 | SMN1; SMN2 (0.68) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 | |
| SCHEMBL9384187 | 0.70 | NPC1 (0.72) | KMT2ASMN1; SMN2ALDH1A1MEN1ALOX15 | |
| SCHEMBL9341104 | 0.70 | KMT2A (0.83) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 | |
| SCHEMBL31658991 | 0.70 | KMT2A (0.83) | KMT2ASMN1; SMN2ALDH1A1MEN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |