Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515626 | 0.85 | NPC1 (0.53) | NPC1RAB9APKMTP53SMN1; SMN2 | |
| SCHEMBL1515392 | 0.80 | NPC1 (0.58) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL14562612 | 0.76 | RAB9A (0.66) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL9586710 | 0.73 | NPC1 (0.56) | NPC1RAB9APKMTP53SMN1; SMN2 | |
| SCHEMBL9586718 | 0.73 | NPC1 (0.56) | NPC1RAB9APKMTP53SMN1; SMN2 | |
| SCHEMBL7876552 | 0.72 | NPC1 (0.50) | NPC1RAB9APKMTP53SMN1; SMN2 | |
| SCHEMBL1185009 | 0.72 | NPC1 (0.63) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL9080412 | 0.72 | NPC1 (0.63) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL7873371 | 0.71 | KMT2A (0.45) | NPC1RAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL7876926 | 0.71 | NPC1 (0.53) | NPC1RAB9APKMSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003966-A1 | N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |