SCHEMBL787341

SCHEMBL787341

[c]1nc2c(-c3nc4ccccc4s3)cccc2o1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 11/20 0.50
RAB9A P51151 10/20 0.50
NPC1 O15118 9/20 0.50
ALDH1A1 P00352 7/20 0.50
MAPT P10636 6/20 0.50
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
SMN1; SMN2 Q16637 5/20 0.50
GAA P10253 4/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
NPSR1 Q6W5P4 1/20 0.43
POLB P06746 3/20 0.43
ILK Q13418 3/20 0.42
GLA P06280 2/20 0.42
HCRTR1 O43613 1/20 0.42
TP53 P04637 3/20 0.41
HSD17B10 Q99714 3/20 0.41
TSHR P16473 1/20 0.41
APP P05067 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29808854 0.76 KDM4E (0.62) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL2846634 0.76 KDM4E (0.62) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL231307 0.75 KDM4E (0.75) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL7131658 0.75
SCHEMBL12854008 0.73 KDM4E (0.72) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL5202659 0.72 TOP2A (0.57) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL1323935 0.72 KDM4E (0.50) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL8032061 0.71 RAB9A (0.56) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL20374776 0.71 RAB9A (0.64) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL2225061 0.71 KDM4E (0.64) KDM4ERAB9ANPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 874 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102317275-B New herbicides SYNGENTA LTD 2015-02-25 CN claimed
CN-102933530-A Novel organic electroluminescent compounds and organic electroluminescent device using the same ROHM & HAAS ELECT MAT 2013-02-13 CN claimed
CN-102361846-A Novel herbicides SYNGENTA LTD 2012-02-22 CN claimed
CN-102291989-A Cyclopentadione derived herbicides 2011-12-21 CN claimed
CN-102101852-A Coumarin derivative, preparation method thereof and application thereof in white light organic electroluminescent device CHINESE ACAD TECH INST PHYSICS 2011-06-22 CN claimed
CN-101613316-A New organic electroluminescent compounds and the Organnic electroluminescent device that uses this compound GRACEL DISPLAY INC 2009-12-30 CN claimed
CN-101516871-A Novel pyridazine derivatives SYNGENTA PARTICIPATIONS AG (CH) 2009-08-26 CN claimed
CN-101516868-A Novel pyridazine derivatives SYNGENTA PARTICIPATIONS AG (CH) 2009-08-26 CN claimed
CN-101448821-A Carboxamide spirolactam cgrp receptor antagonists MERCK & CO INC (US) 2009-06-03 CN claimed
CN-101374817-A Trisubstituted amine compounds as inhibitors of cholesteryl ester transfer protein CETP MITSUBISHI TANABE PHARMA CORP (JP) 2009-02-25 CN claimed
CN-1063014-A Stable composition pesticide TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1992-07-29 CN claimed
CN-1041588-A The imidazolone and the imidazolidinethione class that replace BAYER AG (DE) 1990-04-25 CN claimed
CN-1036954-A The pyrimidine that replaces BAYER AG (DE) 1989-11-08 CN claimed
CN-1036565-A DISUBSTITUTED PYRROLES BAYER AG (DE) 1989-10-25 CN claimed
CN-1034716-A Disubstituted pyridines and preparation method thereof BAYER AG (DE) 1989-08-16 CN claimed
CN-1034364-A Substituted pyridines and process for their preparation BAYER AG (DE) 1989-08-02 CN claimed
CN-1031079-A Alpha-unsaturated amines, process for their production and their use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1989-02-15 CN claimed
CN-1030075-A The pyroles that replaces BAYER AG (DE) 1989-01-04 CN claimed
CN-87101285-A 8-replaces-2-amino-1,2,3, the 4-tetrahydro-bitter edible plant 1988-08-17 CN claimed
EP-0099329-A1 Dithio compounds, pharmaceutical preparations containing them and their use Zyma SA (CH) 1984-01-25 EP claimed