⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457607 | 0.83 | KDM4E (0.31) | — | |
| SCHEMBL116684 | 0.74 | — | — | |
| SCHEMBL19494336 | 0.66 | — | — | |
| SCHEMBL19993240 | 0.66 | — | — | |
| SCHEMBL17208908 | 0.64 | ACHE (0.33) | — | |
| SCHEMBL7068841 | 0.62 | — | — | |
| SCHEMBL12370553 | 0.57 | — | — | |
| SCHEMBL10902977 | 0.57 | — | — | |
| SCHEMBL13620943 | 0.56 | — | — | |
| SCHEMBL9977679 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043988-A4 | C-10 CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE AND ANTITUMOUR ACTIVITIES | HAUSER INC (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6156790-A | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities | HAUSER, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| EP-1043988-A1 | C-10 CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE AND ANTITUMOUR ACTIVITIES | Hauser Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999033461-A1 | C-10 CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE AND ANTITUMOUR ACTIVITIES | HAUSER, INC. (US) | 1999-07-08 | — | — | WO | disclosed |