Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.80 |
| ▸ | PRKACG | P22612 | 2/20 | 0.80 |
| ▸ | PRKACB | P22694 | 2/20 | 0.80 |
| ▸ | CDK4 | P11802 | 1/20 | 0.80 |
| ▸ | CCND1 | P24385 | 1/20 | 0.80 |
| ▸ | PRKCA | P17252 | 2/20 | 0.76 |
| ▸ | PRKCB | P05771 | 1/20 | 0.76 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.76 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | KDR | P35968 | 1/20 | 0.71 |
| ▸ | FLT3 | P36888 | 1/20 | 0.71 |
| ▸ | IDH1 | O75874 | 1/20 | 0.68 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.67 |
| ▸ | PIM1 | P11309 | 2/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.67 |
| ▸ | CDK2 | P24941 | 1/20 | 0.67 |
| ▸ | CDK9 | P50750 | 1/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3139598 | 0.94 | GSK3B (0.78) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL13166904 | 0.94 | CAMK2D (0.78) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL1250687 | 0.92 | GSK3B (0.72) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL30319781 | 0.92 | GSK3B (0.72) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL14522482 | 0.92 | GSK3B (0.69) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL3150613 | 0.90 | PIM1 (0.77) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL8074668 | 0.89 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL8166369 | 0.89 | PIM1 (0.75) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL4988746 | 0.89 | GSK3B (0.66) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL4679424 | 0.89 | CAMK2D (0.80) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657458-B1 | Protein kinase C inhibitors | LILLY CO ELI (US) | 2001-08-22 | — | — | EP | disclosed |
| US-6057440-A | AMINATION AND DEETHERIFICATION OF BISINDOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| US-5624949-A | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-5621098-A | ALKYLATION OF THE CORRESPONDING BISINDOLE COMPOUND; CYCLIZATION; PROTEIN C KINEASE INHIBITOR | ELI LILLY AND COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| US-5552396-A | BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVES, | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0657458-A1 | Protein kinase C inhibitors | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |