Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.75 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.75 |
| ▸ | GSK3B | P49841 | 2/20 | 0.72 |
| ▸ | PRKCA | P17252 | 2/20 | 0.72 |
| ▸ | PRKACA | P17612 | 1/20 | 0.72 |
| ▸ | PRKACG | P22612 | 1/20 | 0.72 |
| ▸ | PRKACB | P22694 | 1/20 | 0.72 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.67 |
| ▸ | CDK4 | P11802 | 2/20 | 0.67 |
| ▸ | CCND1 | P24385 | 2/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CASK | O14936 | 1/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.67 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.67 |
| ▸ | CCNK | O75909 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150613 | 0.99 | PIM1 (0.77) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL3139598 | 0.95 | GSK3B (0.78) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL8161322 | 0.90 | CCNE2 (0.74) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL7873644 | 0.89 | PRKACA (0.80) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL8154114 | 0.88 | CAMK2D (0.91) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL8161268 | 0.86 | CCNT1 (0.75) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL8167286 | 0.86 | PIM1 (0.76) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| Hydrochloric Acid SCHEMBL8160489 | 0.86 | CAMK2D (0.91) | PIM1CAMK2DGSK3BPRKCAPRKACA | |
| SCHEMBL1942352 | 0.86 | CAMK2D (1.00) | PIM1CAMK2DPRKCAPRKACAPRKACG | |
| SCHEMBL8161666 | 0.86 | PIM1 (0.78) | PIM1CAMK2DGSK3BPRKCAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0328026-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-16 | — | — | EP | disclosed |