Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854899 | 0.81 | THRA (0.39) | THRATHRB | |
| SCHEMBL4964591 | 0.74 | THRB (0.51) | THRATHRBRORCALDH1A1 | |
| SCHEMBL6658133 | 0.74 | POLB (0.44) | THRATHRBALDH1A1 | |
| SCHEMBL7512425 | 0.74 | THRA (0.53) | THRATHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6659878 | 0.72 | THRA (0.81) | THRATHRB | |
| SCHEMBL6659761 | 0.72 | THRA (0.85) | THRATHRB | |
| SCHEMBL4963206 | 0.71 | THRB (0.51) | THRATHRBRORCALDH1A1 | |
| SCHEMBL1641063 | 0.70 | THRB (0.58) | THRATHRB | |
| SCHEMBL1642037 | 0.70 | THRA (0.80) | THRATHRB | |
| SCHEMBL1642019 | 0.70 | THRA (0.82) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326398-B1 | Oxamic acids and derivatives as thyroid receptor ligands | PFIZER INC. | 2001-12-04 | — | — | US | disclosed |