Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878053 | 0.92 | SLC6A4 (0.40) | SCN9ASLC6A2SLC6A4NR3C1LPAR1 | |
| SCHEMBL7879496 | 0.91 | SCN9A (0.35) | SCN9ASLC6A2SLC6A4 | |
| SCHEMBL7880193 | 0.91 | SCN9A (0.36) | SCN9AACHEMEN1KMT2A | |
| SCHEMBL7879648 | 0.90 | ACHE (0.35) | ACHEMEN1KMT2A | |
| SCHEMBL7880729 | 0.89 | FFAR1 (0.35) | SCN9ASLC6A2SLC6A4NR3C1LPAR1 | |
| SCHEMBL7877753 | 0.88 | HTR2A (0.39) | SCN9AACHESLC6A4LPAR1LPAR5 | |
| SCHEMBL7880919 | 0.86 | FFAR1 (0.36) | SCN9ASLC6A2SLC6A4FFAR1 | |
| SCHEMBL7881823 | 0.86 | SCN9A (0.30) | SCN9A | |
| Hydrochloric Acid SCHEMBL7881490 | 0.85 | FFAR1 (0.36) | SCN9ASLC6A2SLC6A4FFAR1 | |
| SCHEMBL7882054 | 0.85 | SCN9A (0.37) | SCN9AACHESLC6A2SLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |