Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873759 | 0.92 | SCN9A (0.37) | SLC6A4SLC6A2SCN9AMEN1KMT2A | |
| SCHEMBL7880729 | 0.92 | FFAR1 (0.35) | SLC6A4SLC6A2SCN9ALPAR1LPAR5 | |
| SCHEMBL7873809 | 0.90 | SLC6A4 (0.35) | SLC6A4SLC6A2SCN9AHTR2AFFAR1 | |
| SCHEMBL7877628 | 0.90 | F10 (0.39) | SLC6A4SLC6A2SCN9AHTR2AROCK2 | |
| SCHEMBL7877966 | 0.89 | S1PR1 (0.36) | ROCK2MEN1KMT2AFFAR1RHEB | |
| SCHEMBL7880919 | 0.89 | FFAR1 (0.36) | SLC6A4SLC6A2SCN9AFFAR1RHEB | |
| SCHEMBL7882020 | 0.88 | SLC6A4 (0.45) | SLC6A4SLC6A2HTR2ALPAR1LPAR5 | |
| Hydrochloric Acid SCHEMBL7881490 | 0.88 | FFAR1 (0.36) | SLC6A4SLC6A2SCN9AFFAR1RHEB | |
| SCHEMBL7882372 | 0.88 | FFAR1 (0.39) | FFAR1RHEBBRAF | |
| Hydrochloric Acid SCHEMBL7881831 | 0.87 | SLC6A4 (0.45) | SLC6A4SLC6A2HTR2ALPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |