SCHEMBL7873827

SCHEMBL7873827

CC(C)(CNCCCn1ccnc1)Sc1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
TP53 P04637 2/20 0.54
KDM4E B2RXH2 3/20 0.51
TSHR P16473 1/20 0.51
LMNA P02545 3/20 0.51
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
QPCT Q16769 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.46
PKM P14618 1/20 0.46
MEN1 O00255 2/20 0.46
MAPT P10636 2/20 0.46
HPGD P15428 2/20 0.46
KMT2A Q03164 2/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7873811 0.99 ALDH1A1 (0.53) ALDH1A1TP53KDM4ETSHRLMNA
SCHEMBL7876927 0.82 LMNA (0.54) ALDH1A1TP53LMNACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7879677 0.81 LMNA (0.53) ALDH1A1TP53LMNACYP1A2CYP3A4
SCHEMBL7879667 0.79 LMNA (0.65) ALDH1A1TP53LMNACYP1A2CYP3A4
SCHEMBL7868478 0.78 TP53 (0.74) ALDH1A1TP53KDM4ETSHRCYP1A2
SCHEMBL7877286 0.77 TP53 (0.60) ALDH1A1TP53KDM4ETSHRLMNA
Hydrochloric Acid SCHEMBL7877349 0.76 TP53 (0.59) ALDH1A1TP53KDM4ETSHRLMNA
SCHEMBL14354980 0.75 QPCT (0.55) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL9021146 0.75 TP53 (0.43) ALDH1A1TP53KDM4ETSHRLMNA
SCHEMBL6571544 0.75 CYP1A2 (0.61) ALDH1A1TP53LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326500-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS ABBOTT LABORATORIES 2001-12-04 US disclosed
US-6215001-B1 ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 2001-04-10 US disclosed
US-6031109-A Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents KNOLL AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
US-5780642-A NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 1998-07-14 US disclosed
WO-1995000493-A1 IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS KNOLL AG (DE) 1995-01-05 WO disclosed