Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874643 | 0.89 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7886219 | 0.89 | DGAT1 (0.39) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7883448 | 0.87 | DGAT1 (0.42) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7882451 | 0.81 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7880975 | 0.81 | CHEK1 (0.59) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7878891 | 0.81 | CHEK1 (0.59) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7885824 | 0.81 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7882510 | 0.80 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7878823 | 0.80 | MTOR (0.45) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL6893602 | 0.80 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |