Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10236821 | 0.90 | CHEK1 (0.44) | DGAT1KCNH2MTORRPTORMLST8 | |
| SCHEMBL7886219 | 0.88 | DGAT1 (0.39) | DGAT1KCNH2MTORRPTORMLST8 | |
| SCHEMBL7874478 | 0.87 | MTOR (0.40) | DGAT1KCNH2MTORRPTORMLST8 | |
| SCHEMBL10234279 | 0.83 | CHEK1 (0.44) | DGAT1KCNH2MTORRPTORMLST8 | |
| SCHEMBL10234251 | 0.81 | CHEK1 (0.46) | DGAT1MTORRPTORMLST8CHEK1 | |
| SCHEMBL7885498 | 0.81 | CHEK1 (0.46) | DGAT1MTORRPTORMLST8CHEK1 | |
| SCHEMBL7875038 | 0.80 | CHEK1 (0.46) | DGAT1MTORRPTORMLST8KDM4E | |
| SCHEMBL7882451 | 0.79 | MTOR (0.43) | MTORRPTORMLST8KDM4ENPC1 | |
| SCHEMBL7874817 | 0.79 | MTOR (0.44) | MTORRPTORMLST8KDM4ENPC1 | |
| SCHEMBL7882513 | 0.79 | KMT2A (0.40) | DGAT1MTORRPTORMLST8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |